Time (months)

Sample

Drug content (%), n = 3

% Drug Release, n = 6

f₂

Y₁

Y₂

Y₄

Y₆

Y₈

T = 0

B2

99.48 ± 1.92

13.36

33.19

50.24

72.36

90.96

75.49

B3

100.43 ± 1.31

14.15

35.03

51.83

76.38

90.45

74.53

t = 3

B2

a

104.56 ± 1.39

15.81

36.77

54.17

74.71

92.04

71.48

b

102.43 ± 3.12

16.41

39.39

61.72

83.67

98.55

52.82

B3

a

104.87 ± 1.62

18.79

36.96

53.56

76.30

89.43

69.97

b

102.52 ± 1.35

14.07

31.11

51.98

74.21

93.08

80.64

t = 6

B2

a

104.04 ± 0.72

10.05

25.41

47.90

69.17

88.01

69.03

b

101.58 ± 0.81

12.00

28.13

49.57

70.53

90.30

76.28

B3

a

104.58 ± 1.67

13.22

29.41

51.60

71.04

91.26

79.64

b

104.41 ± 1.25

11.82

31.02

54.04

74.78

91.33

86.29

t = 12

B2 (a)

102.44 ± 1.98

14.69

30.67

53.97

78.44

97.69

76.43

B3 (a)

101.06 ± 2.22

14.00

34.45

55.73

75.61

92.95

73.75